A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells [Corrigendum]
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[This corrects the article on p. 2947 in vol. 10.].
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A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells
Trinucleotide CAG repeat expansion in the coding region of genes has a propensity to form polyglutamine (polyQ) aggregates that contribute to neuronal disorders. Strategies in elevating autophagy to disintegrate the insoluble aggregates without injuring cells have become a major goal for therapy. In this work, a triazole derivative, OC-13, was found accelerating autophagic clearance of polyQ ag...
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